Työnimike: Tutkijatohtori/Postdoctoral researcher

Työnkuvaus:
Aalto University is a community of bold thinkers where science and art meet technology and business. Aalto University has six schools with nearly 20 000 students and 4 700 employees, 390 of which are professors. Our campuses are located in Espoo and Helsinki, Finland. The Molecular Biotechnology group at the School of Chemical Technology is currently looking for a target-oriented person to be hired as: Post-doctoral researcher in the field of Molecular Biotechnology/Proteomics We are looking for a self-motivated, open-minded, goal-oriented, hardworking post-doctoral researcher, with great social competencies and a good sense of humor to strengthen and broaden our on-going activities in developing yeast-based cell factories for production of therapeutic antibodies. The projects combines proteomics, molecular biology and mathematical modelling work. We have created a technology with a cutting edge potential for the production of therapeutic proteins - a glycoengineered yeast producing human-like N-glycans (Piirainen et al., 2016). However, many bottlenecks are still restricting the use of yeast systems for expression of therapeutic N-glycosylated proteins in an economically viable way. Therefore, we are currently focusing on increasing the yeasts capacity for producing antibodies by upgrading its endoplasmic reticulum (de Ruijter et al., 2016). The project will scrutinize the protein folding process and the folding environment in order to identify the molecular basis for these bottlenecks. Furthermore, we will explore the plasticity of the folding environment and extend our current work for its targeted functionalization for antibody folding. We offer an international research environment with the opportunity to conduct highly competitive research. The successful candidate is expected to contribute to on-going projects and / or actively develop his or her own research profile. We have access to state-of-the-art Bruker ESI-ETD-Iontrap MS and Ultraflex MALDI TOF/TOF MS instruments, and flow cytometer. In addition, the candidate is expected to contribute to teaching. The salary is based on the Local Agreement of Aalto University. The candidate must hold a Ph.D. degree in Biotechnology or equivalent. The candidate must have proven expertise in the fields of proteomics, glycoproteomics and/or glyomics and molecular biology. Expertise in yeast genetics is an asset. He or she should have a track record in conducting innovative scientific research and publishing in high-ranking scientific journals. The ability to work effectively and independently as well as good social skills are expected. The candidate is expected to support other group members in the area of mass spectrometry. Your application should include a letter of motivation, curriculum vitae, publication list, at least two publications relevant for the position, 2 letters of recommendation, and transcripts from MSc and Ph.D./D.Sc. degrees. Applications with attachments (in pdf-format) are to be submitted through the eRecruitment system no later than August 10th, 2016. For further information please contact Associate Professor Alexander Frey, email: firstname.lastname (at) aalto.fi. The application materials will not be returned. Aalto University reserves the right for justified reasons to leave the position open, to extend the application period and to consider candidates who have not submitted applications during the application period.

Työnantajan nimi: Aalto-yliopisto

Työnantajan osoite: Kemistintie 1, 02150 ESPOO

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Työn lyhyt kuvaus: Muut tekniikan erityisasiantuntijat

Maa: Suomi

Alue: Helsinki-Uusimaa

Sopimuksen kesto: Tilapäinen

Sopimuslaji: Kokopäiväinen

Lähde työtarjous:
MOL/Työ- ja elinkeinoministeriö, Julkiset työvoimapalvelut, Suomi